Genome‐Wide Location Analysis by Pull Down of In Vivo Biotinylated Transcription Factors

Genome-wide location analysis by pull down of in vivo biotinylated transcription factors.

Recent development of methods for genome-wide identification of transcription factor binding sites by chromatin immunoprecipitation (ChIP) has led to novel insights into transcriptional regulation and greater understanding of the function of individual transcription factors. ChIP requires highly specific antibody against the transcriptional regulator of interest, and availability of suitable an...

microRNA target identification by RNA pull down with biotinylated microRNA mimics

New exciting experimental approaches to transcriptome-wide identification of microRNA binding sites are revealing surprising details about microRNA interaction with RNA targets. Approximately one out of five microRNA interactions occur without canonical perfect base pairing to the seed sequence. Instead they are often governed by imperfect binding to the center of the microRNA. One primate spec...

Down Regulation of DHFR Promoter Activity by PML Transcription Repressor

analysis of power in the network society

اندیشمندان و صاحب نظران علوم اجتماعی بر این باورند که مرحله تازه ای در تاریخ جوامع بشری اغاز شده است. ویژگیهای این جامعه نو را می توان پدیده هایی از جمله اقتصاد اطلاعاتی جهانی ، هندسه متغیر شبکه ای، فرهنگ مجاز واقعی ، توسعه حیرت انگیز فناوری های دیجیتال، خدمات پیوسته و نیز فشردگی زمان و مکان برشمرد. از سوی دیگر قدرت به عنوان موضوع اصلی علم سیاست جایگاه مهمی در روابط انسانی دارد، قدرت و بازتولید...

In vivo Analysis of H2AX Phosphorylation Induced by γ-Radiation

ABSTRACT          Background and Objectives: Exposure to ionizing radiation in modern societies is inevitable and can cause a variety of adverse health effects such as cancer and birth defects. Therefore, a reliable, repeatable and sensitive method is required for evaluation of radiation exposure. The aim of this study was to determine the amount of hist...